Production of valuable drugs from plant cells immobilized by hybrid sol-gel SiO sub(2)

Catharantus roseus cells are supported on a polyester fiber mat and encapsulated by a porous layer of SiO sub(2) modified by Si-CH sub(3) and Si-H bonds. This layer is obtained by reaction of Si-alkoxides in the gas phase with H sub(2)O adsorbed on the cell surface or with exposed -OH groups of cell...

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Bibliographic Details
Published in:Journal of sol-gel science and technology 1998-01, Vol.13 (1-3), p.273-276
Main Authors: Carturan, G, Dal Monte, R, Pressi, G, Secondin, S, Verza, P
Format: Article
Language:English
Subjects:
Adsorption
Biotechnology
Cell immobilization
Cell membranes
Chemical bonds
Metabolites
Plastic filaments
Polyesters
Silica gel
Sol-gels
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Summary:Catharantus roseus cells are supported on a polyester fiber mat and encapsulated by a porous layer of SiO sub(2) modified by Si-CH sub(3) and Si-H bonds. This layer is obtained by reaction of Si-alkoxides in the gas phase with H sub(2)O adsorbed on the cell surface or with exposed -OH groups of cellulosic cell membrane. Viability and alkaloid production of cells are maintained after encapsulation. An experimental reactor allows study of secondary metabolite productivity, which is increased by two orders of magnitude with respect to that of free cells. Sucrose consumption kinetics are also studied and related to the viability of encapsulated cells.
ISSN:0928-0707