Growing international evidence for urinary biomarker panels identifying lupus nephritis in children – verification within the South African Paediatric Lupus Cohort

Background A urinary biomarker panel including alpha-1-acid-glycoprotein (AGP), lipocalin-like-prostaglandin-D-synthase (LPGDS), transferrin and ceruloplasmin demonstrates an ‘excellent’ ability for identifying active lupus nephritis in UK/US children. This study aimed to assess whether this panel i...

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Bibliographic Details
Published in:Lupus 2018-12, Vol.27 (14), p.2190-2199
Main Authors: Smith, E M D, Lewandowski, L B, Jorgensen, A L, Phuti, A, Nourse, P, Scott, C, Beresford, M W
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Biomarkers
Biomarkers - urine
Case-Control Studies
Ceruloplasmin
Ceruloplasmin - urine
Child
Children
Cohort Studies
Enzyme-linked immunosorbent assay
Female
Health risk assessment
Humans
Intramolecular Oxidoreductases - urine
Lipocalin
Lipocalins - urine
Logistic Models
Lupus
Lupus nephritis
Lupus Nephritis - diagnosis
Lupus Nephritis - urine
Male
Nephritis
Orosomucoid - urine
South Africa
Systemic lupus erythematosus
Transferrin
Transferrin - urine
Vascular cell adhesion molecule 1
Vascular Cell Adhesion Molecule-1 - urine
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Summary:Background A urinary biomarker panel including alpha-1-acid-glycoprotein (AGP), lipocalin-like-prostaglandin-D-synthase (LPGDS), transferrin and ceruloplasmin demonstrates an ‘excellent’ ability for identifying active lupus nephritis in UK/US children. This study aimed to assess whether this panel identifies active lupus nephritis within the South African Paediatric Lupus Cohort. Methods Juvenile-onset-systemic lupus erythematosus (JSLE) patients aged 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203318808376