Astaxanthin protects lipopolysaccharide-induced inflammatory response in Channa argus through inhibiting NF-κB and MAPKs signaling pathways

The present study was conducted to evaluate the protective effects of astaxanthin against lipopolysaccharide (LPS)-induced inflammatory responses in Channa argus in vivo and ex vivo. Primary hepatocytes were exposed to different concentrations of LPS for 24 h to induce an inflammatory response, and...

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Bibliographic Details
Published in:Fish & shellfish immunology 2019-03, Vol.86, p.280-286
Main Authors: Li, Mu-Yang, Sun, Li, Niu, Xiao-Tian, Chen, Xiu-Mei, Tian, Jia-Xin, Kong, Yi-Di, Wang, Gui-Qin
Format: Article
Language:English
Subjects:
Astaxanthin
Channa argus
Inflammatory responses
Lipopolysaccharide
NF-κB and MAPK signaling pathways
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Summary:The present study was conducted to evaluate the protective effects of astaxanthin against lipopolysaccharide (LPS)-induced inflammatory responses in Channa argus in vivo and ex vivo. Primary hepatocytes were exposed to different concentrations of LPS for 24 h to induce an inflammatory response, and the protective effects of astaxanthin against LPS-induced inflammation were studied ex vivo and in vivo. Hepatocytes exposed to LPS (5–20 μg mL−1) alone for 24 h resulted in a significant increase in lactate dehydrogenase release (LDH), Nitric oxide (NO) production and Malondialdehyde (MDA) content, 10 μg mL−1 LPS could induced inflammatory response in hepatocytes. Gene expression of TLR4, NFkBp65, MAPKp38, TNF-α, IL-6 and IL-1β mRNA expression were also enhanced ex vivo (p 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2018.11.011