A clickable caging group as a new platform for modular caged compounds with improved photochemical properties

A 6-bromo-7-hydroxycoumarin-4-ylmethyl (Bhc) caged compound having a click-modifiable chemical handle was designed and synthesized. This molecule was applied to the synthesis of modular caged paclitaxels (PTXs) in which additional functional units could be easily installed. This system was used to p...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (4), p.451-454
Main Authors: Suzuki, Akinobu Z, Sekine, Ryota, Takeda, Shiori, Aikawa, Ryosuke, Shiraishi, Yukiko, Hamaguchi, Tomomi, Okuno, Hiroyuki, Tamamura, Hirokazu, Furuta, Toshiaki
Format: Article
Language:English
Subjects:
Cage compounds
Chemical synthesis
Organic chemistry
Photolysis
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Summary:A 6-bromo-7-hydroxycoumarin-4-ylmethyl (Bhc) caged compound having a click-modifiable chemical handle was designed and synthesized. This molecule was applied to the synthesis of modular caged paclitaxels (PTXs) in which additional functional units could be easily installed. This system was used to prepare water-soluble caged PTXs with improved photolysis efficiencies.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07981a