The other side of the superoxide radical anion: its ability to chemically repair DNA oxidized sites

The superoxide radical anion can repair oxidative damage. In particular, it was demonstrated that O2˙- can repair oxidized DNA by electron transfer, restoring the original structure of this important molecule. Acid-base equilibria have been considered, and the influence of the pH on the main reactio...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-12, Vol.54 (97), p.13710-13713
Main Authors: Muñoz-Rugeles, Leonardo, Galano, Annia, Alvarez-Idaboy, Juan Raúl
Format: Article
Language:English
Subjects:
Anions
Anions - chemistry
Binding Sites
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA Damage
Electron transfer
Electron Transport
Hydrogen-Ion Concentration
Molecular structure
Organic chemistry
Oxidation
Oxidation-Reduction
Reaction mechanisms
Repair
Superoxides - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The superoxide radical anion can repair oxidative damage. In particular, it was demonstrated that O2˙- can repair oxidized DNA by electron transfer, restoring the original structure of this important molecule. Acid-base equilibria have been considered, and the influence of the pH on the main reaction mechanism has been explored.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07834c