Antiphospholipid antibodies and renal transplant: A systematic review and meta-analysis

To evaluate the effect of antiphospholipid antibodies (aPL) on renal allograft outcome after kidney transplantation. A systematic search of EMBASE and PubMed databases from inception to July 2018 was run according to PRISMA guidelines; Peto's odds ratio (OR) for rare events was used for the met...

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Bibliographic Details
Published in:Seminars in arthritis and rheumatism 2019-06, Vol.48 (6), p.1041-1052
Main Authors: Ames, Paul RJ, Merashli, Mira, Bucci, Tommaso, Gentile, Fabrizio, Delgado-Alves, Jose
Format: Article
Language:English
Subjects:
Antibodies, Antiphospholipid - immunology
Antiphospholipid antibodies
Graft Survival - immunology
Humans
Kidney Transplantation
Renal transplantation
Treatment Outcome
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Summary:To evaluate the effect of antiphospholipid antibodies (aPL) on renal allograft outcome after kidney transplantation. A systematic search of EMBASE and PubMed databases from inception to July 2018 was run according to PRISMA guidelines; Peto's odds ratio (OR) for rare events was used for the meta-analysis. Our inclusion/exclusion criteria were met by 22 cohort studies having different outcomes: allograft thrombosis (n = 9) and thromboprophylaxis (n = 3), allograft loss from any cause (n = 9), allograft malfunction (n = 3), duration (n = 2), glomerular filtration rate at 1 year (n = 3) and allograft rejection (n = 5). The pooled prevalence of allograft thrombosis and of thrombotic microangiopathy was greater in aPL+ve than negative recipients (10.4% vs 1.7%, p 
ISSN:0049-0172
1532-866X
DOI:10.1016/j.semarthrit.2018.10.016