Central contributions to torque depression: an antagonist perspective

• Published in: Experimental brain research 2019-02, Vol.237 (2), p.443-452
• Main Authors: Sypkes, Caleb T., Contento, Vincenzo S., Bent, Leah R., McNeil, Chris J., Power, Geoffrey A.
• Format: Article
• Language: English
• Subjects: Adult; Ankle; Biomedical and Life Sciences; Biomedicine; Central nervous system; Cerebral Cortex - physiology; Depression (Mood disorder); Electric Stimulation - methods; Electromyography; Electromyography - methods; Evoked Potentials, Motor - physiology; Excitability; Female; Humans; Isometric exercise; Male; Mental depression; Motor evoked potentials; Muscle contraction; Muscle Contraction - physiology; Muscle, Skeletal - physiology; Neurology; Neurosciences; Peripheral Nerves - physiology; Plantar flexion; Pyramidal tracts; Research Article; Risk factors; Soleus muscle; Spinal Cord - physiology; Torque; Transcranial Magnetic Stimulation - methods; Young Adult
• ISSN: 0014-4819; 1432-1106
• DOI: 10.1007/s00221-018-5435-8

Torque depression (TD) is the reduction in steady-state isometric torque following active muscle shortening when compared to an isometric reference contraction at the same muscle length and activation level. Central nervous system excitability differs in the TD state. While torque production about a joint is influenced by both agonist and antagonist muscle activation, investigations of corticospinal excitability have focused on agonist muscle groups. Hence, it is unknown how the TD state affects spinal and supraspinal excitability of an antagonist muscle. Eight participants (~ 24y, three female) performed 14 submaximal dorsiflexion contractions at the intensity needed to maintain a level of integrated electromyographic activity in the soleus equivalent to 15% of that recorded during a maximum plantar flexion contraction. The seven contractions of the TD protocol included a 2 s isometric phase at an ankle angle of 140°, a 1 s shortening phase at 40°/s, and a 7 s isometric phase at an angle of 100°. The seven isometric reference contractions were performed at an ankle angle of 100° for 10 s. Motor evoked potentials (MEPs), cervicomedullary motor evoked potentials (CMEPs), and maximal M-waves (Mmax) were recorded from the soleus in both conditions. In the TD compared to isometric reference state, a 13% reduction in dorsiflexor torque was accompanied by 10% lower spinal excitability (normalized CMEP amplitude; CMEP/Mmax), and 17% greater supraspinal excitability (normalized MEP amplitude; MEP/CMEP) for the soleus muscle. These findings demonstrate a neuromechanical coupling following active muscle shortening and indicate that the underlying mechanisms of TD influence antagonist activation during voluntary force production.