Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to m...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2019-01, Vol.162, p.378-395
Main Authors: Scarim, Cauê Benito, Jornada, Daniela Hartmann, Machado, Marcella Gabrielle Mendes, Ferreira, Carla Maria Riberio, dos Santos, Jean Leandro, Chung, Man Chin
Format: Article
Language:English
Subjects:
Chagas disease
Drug development
New drugs
Semicarbazone
T. cruzi
Thiazole
Thiosemicarbazone
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Summary:Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to medicinal chemistry in the last five years, focusing on tropical infectious diseases, such as Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. We also present perspectives for their use in drug design in order to contribute to the development of new drugs. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2018.11.013