Functional Imaging with Nucleic‐Acid‐Based Sensors: Technology, Application and Future Healthcare Prospects

Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signa...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2019-02, Vol.20 (4), p.437-450
Main Authors: Wiraja, Christian, Yeo, David C., Lio, Daniel Chin Shiuan, Zheng, Mengjia, Xu, Chenjie
Format: Article
Language:English
Subjects:
activatable probes
biosensors
functional imaging
Health care
Medical electronics
Nanotechnology
Nucleic acids
Optical measuring instruments
Reagents
Sensors
Therapeutic applications
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Summary:Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio‐applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications. Activatable probes: This review highlights recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio‐applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation to clinical applications.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201800430