Effect of cytomegalovirus infection and leukocyte immunoglobulin like receptor B1 polymorphisms on receptor expression in peripheral blood mononuclear cells

ABSTRACT Leukocyte immunoglobulin like receptor B1 (LILRB1) plays a significant role in a number of infectious, autoimmune, cardiovascular, and oncologic disorders. LILRB1 expression varies between individuals and may be associated with polymorphisms on the regulatory region of the LILRB1 gene, as w...

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Bibliographic Details
Published in:Microbiology and immunology 2018-12, Vol.62 (12), p.755-762
Main Authors: Cadena‐Mota, Sandra, Monsiváis‐Urenda, Adriana, Salgado‐Bustamante, Mariana, Monjarás‐Ávila, César, Bernal‐Silva, Sofía, Aranda‐Romo, Saray, Noyola, Daniel E.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - blood
Antigens, CD - blood
B-Lymphocytes - immunology
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus - pathogenicity
Cytomegalovirus Infections - blood
Cytomegalovirus Infections - immunology
Female
Gene Expression Regulation - genetics
Gene Expression Regulation - immunology
Haplotypes
Humans
Immunoglobulins
Infections
Killer Cells, Natural - immunology
leukocyte immunoglobulin like receptor B1
Leukocyte Immunoglobulin-like Receptor B1 - blood
Leukocyte Immunoglobulin-like Receptor B1 - genetics
Leukocyte Immunoglobulin-like Receptor B1 - metabolism
Leukocytes (mononuclear)
Leukocytes, Mononuclear - metabolism
Lymphocytes
Lymphocytes B
Lymphocytes T
Male
Monocytes
natural killer cells
Peripheral blood mononuclear cells
Polymorphism, Genetic
polymorphisms
Receptors, Immunologic - genetics
T-Lymphocytes - immunology
Young Adult
Young adults
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Summary:ABSTRACT Leukocyte immunoglobulin like receptor B1 (LILRB1) plays a significant role in a number of infectious, autoimmune, cardiovascular, and oncologic disorders. LILRB1 expression varies between individuals and may be associated with polymorphisms on the regulatory region of the LILRB1 gene, as well as to previous cytomegalovirus infection. In this study, the contribution of these two factors to LILRB1 expression in peripheral blood mononuclear cells of healthy young adults was analyzed. LILRB1 expression in NK cells, T cells, B cells and monocytes was significantly stronger in individuals who had had cytomegalovirus infection than in those who had not (P 
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12661