Determining detector requirements for medical imaging applications

The Cramér–Rao lower bound on estimator variance is used as a tool for assessing radiation detector requirements for nuclear medicine imaging. The classical bound for unbiased estimators is reviewed and its relationship to the well-known propagation-of-error formula is demonstrated. The uniform Cram...

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Bibliographic Details
Published in:Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment Accelerators, spectrometers, detectors and associated equipment, 1998-05, Vol.409 (1-3), p.501-507
Main Authors: Clinthorne, Neal H., Ng, Chor-yi, Strobel, Joerg, Hua, Chia-ho, LeBlanc, James W., Wilderman, Scott J., Rogers, W.Leslie
Format: Article
Language:English
Subjects:
Cameras
Cramér–Rao lower bound
Medical imaging
Noise
Noise-propagation
Nuclear medicine
Optical collimators
Photodiodes
Scintillation
Semiconducting indium compounds
Silicon sensors
Spurious signal noise
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Summary:The Cramér–Rao lower bound on estimator variance is used as a tool for assessing radiation detector requirements for nuclear medicine imaging. The classical bound for unbiased estimators is reviewed and its relationship to the well-known propagation-of-error formula is demonstrated. The uniform Cramér–Rao bound is described for situations where unbiased estimation is impractical such as in tomographic imaging. The bounds are used to evaluate the necessary detector requirements for a CsI(Tl)/Si photodiode scintillation camera, and to compare the performance of a Compton-scatter camera to that of a parallel-hole collimator/Anger camera system.
ISSN:0168-9002
1872-9576
DOI:10.1016/S0168-9002(97)01303-X