Early biokinetics of actinides after intravenous administration of soluble forms of Pu(IV), Np(IV) and Np(V)

We have compared the early biokinetics of actinides after intravenous administration of Pu(IV)–citrate, Np(IV)–citrate or Np(V)–nitrate in male Sprague-Dawley rats. Blood samples, the liver, the kidneys and the femurs were removed 1, 2, 6 and 24 h after contamination for radioactive measurements. Ou...

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Bibliographic Details
Published in:Journal of alloys and compounds 1998-06, Vol.271, p.103-105
Main Authors: Ramounet, B, Matton, S, Grillon, G, Fritsch, P
Format: Article
Language:English
Subjects:
Biokinetics
Blood
Bone
Esters
Neptunium
Plutonium
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Summary:We have compared the early biokinetics of actinides after intravenous administration of Pu(IV)–citrate, Np(IV)–citrate or Np(V)–nitrate in male Sprague-Dawley rats. Blood samples, the liver, the kidneys and the femurs were removed 1, 2, 6 and 24 h after contamination for radioactive measurements. Our results demonstrate significant differences in blood and bone actinide retention for each compound studied. We conclude that the biological Np behavior varies depending on its valency state. Np(V) readily binds to the skeleton, whereas a gradual delay in the bone retention kinetics was observed for Np(IV) and Pu(IV), respectively.
ISSN:0925-8388
1873-4669
DOI:10.1016/S0925-8388(98)00034-6