Synthesis of CMe2CF3‑Containing Heteroarenes via Tandem 1,1-Dimethyltrifluoroethylation and Cyclization of Isonitriles

A tandem 1,1-dimethyltrifluoroethylation and cyclization of isonitriles with 3,3,3-trifluoro-2,2-dimethylpropanoic acid was developed. This protocol provides the efficient synthesis of a series of previously unknown CMe2CF3-containing heteroarenes, which are potentially useful in the drug discovery...

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Bibliographic Details
Published in:Journal of organic chemistry 2018-12, Vol.83 (24), p.15236-15244
Main Authors: Shi, Wen-Qiang, Liu, Shuai, Wang, Chen-Ze, Huang, Yangen, Qing, Feng-Ling, Xu, Xiu-Hua
Format: Article
Language:English
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Summary:A tandem 1,1-dimethyltrifluoroethylation and cyclization of isonitriles with 3,3,3-trifluoro-2,2-dimethylpropanoic acid was developed. This protocol provides the efficient synthesis of a series of previously unknown CMe2CF3-containing heteroarenes, which are potentially useful in the drug discovery process.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b02506