Cognitive function assessment in elderly patients with overactive bladder treated with transdermal oxybutynin

• Published in: Actas urológicas españolas (English ed.) 2019-04, Vol.43 (3), p.143-150
• Main Authors: Müller-Arteaga, C, Batista-Miranda, J E, Zubiaur Libano, C, El Khoury Moreno, R, Morales Solchaga, G, Casas Nebra, J, Leva Vallejo, M, Gonzalez Garcia, O, Errando-Smet, C, Arlandis-Guzman, S
• Format: Article
• Language: eng ; spa
• ISSN: 2173-5786
• DOI: 10.1016/j.acuro.2018.07.005

INTRODUCTION AND OBJECTIVESOlder patients with overactive bladder under antimuscarinic treatment are especially susceptible to cognitive impairment. The aim was to assess short term changes in cognitive function in elderly patients with overactive bladder treated with transdermal oxybutynin. MATERIALS AND METHODSObservational, retrospective, multicentre study in patients with overactive bladder aged 65-80 years undergoing treatment with transdermal oxybutynin. Before and after one month of treatment, cognitive function using the Memory Alteration Test and Clock-Drawing Test, changes in symptoms with validated questionnaires, patient perception of treatment response using Treatment Benefit Scale and treatment adherence with the modified Morisky-Green test, were assessed. RESULTSFrom 85 eligible patients, 70 completed the assessment (mean age: 71.4±4.5; BMI: 28.7±3.1kg/m2). No cognitive impairment was observed after one month with transdermal oxybutynin: Memory Alteration Test (+1 point; 95%CI: 0.0-1.5), Clock-Drawing Test (0 points; 95%CI: 0.0-0.0). A statistically significant improvement (P