Nuclear elemental analyses with a cyclotron on biomedical samples

The Eindhoven scanning proton microprobe enables the determination of the ion content of heart tissue on a sub-cellular scale. It is shown that intra-cellular elemental concentrations can be determined. Measurements are carried out for physiological and patho-physiological rat heart muscle tissue. I...

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Bibliographic Details
Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 1999-07, Vol.156 (1), p.252-257
Main Authors: Quaedackers, J.A., de Voigt, M.J.A., Mutsaers, P.H.A., de Goeij, J.J.M., van der Vusse, G.J.
Format: Article
Language:English
Subjects:
Biomedical samples
Cardiovascular system
Cobalt compounds
Cyclotrons
Emission spectroscopy
Ion beams
Ion-beam analysis
NFS
Physiology
PIXE
Potassium
RBS
Rutherford backscattering spectroscopy
Sodium
X ray spectroscopy
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Summary:The Eindhoven scanning proton microprobe enables the determination of the ion content of heart tissue on a sub-cellular scale. It is shown that intra-cellular elemental concentrations can be determined. Measurements are carried out for physiological and patho-physiological rat heart muscle tissue. Important alterations in Na and K concentrations are reported as measured with PIXE, RBS and NFS techniques employing a variable energy cyclotron (3–30 MeV). However, quantitative intra-cellular determinations are hampered by the presence of extra-cellular space (ECS). For this purpose, cobaltic ethylene-diamine-tetra-acetic-acid (Co(III)EDTA) was used as an exogenic ECS marker. The intra-cellular ion concentrations of normoxic tissue after correction for the ECS agree well with the literature values.
ISSN:0168-583X
1872-9584
DOI:10.1016/S0168-583X(99)00248-7