Serum Sickness-Like Reaction Associated with Inactivated Influenza Vaccination among Thai Health Care Personnel: Risk Factors and Outcomes

Fourteen (3%) of 495 Thai health care personnel were identified as having a serum sickness-like reaction in 2008 after receipt of inactivated influenza vaccine manufactured in Thailand. These health care personnel experienced fever, myalgia, centrifugal arthralgias, and injection site erythema. A hi...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-07, Vol.49 (1), p.e18-e22
Main Authors: Apisarnthanarak, Anucha, Uyeki, Timothy M., Miller, Elaine R., Mundy, Linda M.
Format: Article
Language:English
Subjects:
Adult
Aged
Arthralgia
Drugs
Erythema
Female
Fever
Food hypersensitivity
Health Personnel
Humans
Influenza
Influenza Vaccines - adverse effects
Male
Middle Aged
Myalgia
Personnel
Risk Factors
Serum Sickness - chemically induced
Thailand
Treatment Outcome
Vaccination
Vaccines
Young Adult
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Description
Summary:Fourteen (3%) of 495 Thai health care personnel were identified as having a serum sickness-like reaction in 2008 after receipt of inactivated influenza vaccine manufactured in Thailand. These health care personnel experienced fever, myalgia, centrifugal arthralgias, and injection site erythema. A history of allergic reactions to food or drugs (adjusted odds ratio, 5.9; 95% confidence interval, 1.54–25.4) was independently associated with a serum sickness-like reaction.
ISSN:1058-4838
1537-6591
DOI:10.1086/599615