Severe vemurafenib‐induced photosensitivity in a 6‐year‐old boy

Vemurafenib, a selective BRAF kinase inhibitor, has been found to induce several cutaneous adverse effects, ranging from a keratosis pilaris‐like reaction to squamous cell carcinoma. While photosensitivity has been well described as one of these manifestations, we report a case of a 6‐year‐old boy o...

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Bibliographic Details
Published in:Pediatric dermatology 2019-01, Vol.36 (1), p.e62-e63
Main Authors: Jew, Olivia S., Provini, Lauren E., Treat, James R.
Format: Article
Language:English
Subjects:
Case reports
Chemotherapy
drug reaction
Enzyme inhibitors
Inhibitor drugs
Keratosis
neoplasms—malignant
Pediatrics
Photosensitivity
Side effects
Skin cancer
Squamous cell carcinoma
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Summary:Vemurafenib, a selective BRAF kinase inhibitor, has been found to induce several cutaneous adverse effects, ranging from a keratosis pilaris‐like reaction to squamous cell carcinoma. While photosensitivity has been well described as one of these manifestations, we report a case of a 6‐year‐old boy on vemurafenib who developed a severe blistering sunburn after only two 30‐minute episodes of sun exposure. A brief review of other common cutaneous adverse effects of vemurafenib is also provided.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.13720