Carvacrol ameliorates experimental autoimmune encephalomyelitis through modulating pro- and anti-inflammatory cytokines

The inflammatory process is a key step in multiple sclerosis (MS) development. Carvacrol exhibits various anti-inflammatory properties. We aimed to assess the Carvacrol effects on clinical manifestations and production of pro-inflammatory (IFN-γ, IL-6 and IL-17) and anti-inflammatory (TGF-β, IL-4, a...

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Bibliographic Details
Published in:Life sciences (1973) 2019-02, Vol.219, p.257-263
Main Authors: Mahmoodi, Merat, Amiri, Houshang, Ayoobi, Fatemeh, Rahmani, Mehdi, Taghipour, Zahra, Ghavamabadi, Razieh Taghizadeh, Jafarzadeh, Abdollah, Sankian, Mojtaba
Format: Article
Language:English
Subjects:
Carvacrol
Cytokines
Experimental autoimmune encephalomyelitis
Inflammation
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Summary:The inflammatory process is a key step in multiple sclerosis (MS) development. Carvacrol exhibits various anti-inflammatory properties. We aimed to assess the Carvacrol effects on clinical manifestations and production of pro-inflammatory (IFN-γ, IL-6 and IL-17) and anti-inflammatory (TGF-β, IL-4, and IL-10) cytokines in experimental autoimmune encephalomyelitis (EAE) as MS animal model. EAE mice were treated with 5, 10 mg/kg dose of Carvacrol or vehicle, as the control EAE group, every other day until day-21 post EAE induction. On day22, the leukocyte infiltration within the CNS was estimated using hematoxylin-eosin staining. The cytokine production by splenocytes was determined after in vitro stimulating with myelin oligodendrocyte protein (MOG). The EAE clinical scores in 5 and 10 mg/kg Carvacrol-treated mice were lower than untreated group (P 
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2018.11.051