Lipid metabolism in Alzheimer’s disease

•This review summarized the relationship between lipid metabolism and AD.•It suggested lipid has the potential effect to relieve the symptoms of AD.•It classified the types of lipids concerned with CNS and their transport to brain. Since the metabolic disorder may be the high risk that contribute to...

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Bibliographic Details
Published in:Brain research bulletin 2019-01, Vol.144, p.68-74
Main Authors: Zhu, Tian-Bi, Zhang, Zhao, Luo, Piao, Wang, Sha-Sha, Peng, Ye, Chu, Shi-Feng, Chen, Nai-Hong
Format: Article
Language:English
Subjects:
Adipokines - metabolism
Adipose Tissue - pathology
Alzheimer Disease - metabolism
Alzheimer’s disease
Brain - metabolism
Brain - pathology
Central nervous system
Diet
Humans
Lipid
Lipid Metabolism - physiology
Mesenchymal Stem Cells - physiology
Metabolism
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Summary:•This review summarized the relationship between lipid metabolism and AD.•It suggested lipid has the potential effect to relieve the symptoms of AD.•It classified the types of lipids concerned with CNS and their transport to brain. Since the metabolic disorder may be the high risk that contribute to the progress of Alzheimer’s disease (AD). Overtaken of High-fat, high-glucose or high-cholesterol diet may hasten the incidence of AD in later life, due to the metabolic dysfunction. But the metabolism of lipid in brain and the exact effect of lipid to brain or to the AD’s pathological remain controversial. Here we summarize correlates of lipid metabolism and AD to provide more foundation for the daily nursing of AD sensitive patients.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2018.11.012