Cytokines as Mediators of Neuroinflammation in Experimental Autoimmune Encephalomyelitis

Cytokines play a pivotal role in maintaining homeostasis of the immune system and in regulation of the immune response. Cytokine dysregulation is often associated with development of various pathological conditions, including autoimmunity. Recent studies have provided insights into the cytokine sign...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2018-09, Vol.83 (9), p.1089-1103
Main Authors: Gogoleva, V. S., Atretkhany, K. -S. N., Drutskaya, M. S., Mufazalov, I. A., Kruglov, A. A., Nedospasov, S. A.
Format: Article
Language:English
Subjects:
Animal models
Animals
Antibodies, Monoclonal - therapeutic use
Autoimmunity
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cellular signal transduction
Cytokines
Cytokines - metabolism
Development and progression
Encephalomyelitis
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - metabolism
Encephalomyelitis, Autoimmune, Experimental - pathology
Experimental allergic encephalomyelitis
Health aspects
Homeostasis
Humans
Immune response
Immune system
Inflammation
Life Sciences
Microbiology
Molecular modelling
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
Neurodegenerative Diseases - immunology
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Neurons - metabolism
Pathogenesis
Physiological aspects
Review
Signal Transduction
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
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Summary:Cytokines play a pivotal role in maintaining homeostasis of the immune system and in regulation of the immune response. Cytokine dysregulation is often associated with development of various pathological conditions, including autoimmunity. Recent studies have provided insights into the cytokine signaling pathways that are involved not only in pathogenesis of autoimmune neuroinflammatory disorders, such as multiple sclerosis, but also in neurodegenerative states, for example, Alzheimer’s disease. Understanding the exact molecular mechanisms of disease pathogenesis and evaluation of relevant experimental animal models are necessary for development of effective therapeutic approaches.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918090110