Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis

Summary Background Vitamin D deficiency has been implicated in the outcome of chronic liver disease. Aim To determine the frequency of severe vitamin D deficiency in autoimmune hepatitis (AIH), assess its association with treatment non‐response, and evaluate the relationship between vitamin D status...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2019-01, Vol.49 (2), p.173-182
Main Authors: Ebadi, Maryam, Bhanji, Rahima A., Mazurak, Vera C., Lytvyak, Ellina, Mason, Andrew, Czaja, Albert J., Montano‐Loza, Aldo J.
Format: Article
Language:English
Subjects:
Adult
Alanine
Alanine transaminase
Aspartate aminotransferase
Biomarkers
Biomarkers - blood
Cirrhosis
Female
Hepatitis
Hepatitis, Autoimmune - blood
Hepatitis, Autoimmune - diagnosis
Hepatitis, Autoimmune - epidemiology
Humans
Immunoglobulin G
Immunosuppressive agents
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Liver diseases
Liver transplantation
Middle Aged
Mortality
Patients
Prognosis
Retrospective Studies
Serum levels
Severity of Illness Index
Statistical models
Supplements
Transplantation
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - epidemiology
Vitamin deficiency
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Summary:Summary Background Vitamin D deficiency has been implicated in the outcome of chronic liver disease. Aim To determine the frequency of severe vitamin D deficiency in autoimmune hepatitis (AIH), assess its association with treatment non‐response, and evaluate the relationship between vitamin D status and liver‐related mortality and need for transplantation. Methods Two hundred and nine patients were evaluated by liver tissue examination at presentation. Serum vitamin D levels were determined, and serum levels
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.15029