Male infertility in Sertoli cell‐only syndrome: An investigation of autosomal gene defects

Objectives To detect autosomal genetic defects and to determine candidate genes in Sertoli cell‐only syndrome infertile men. Methods Single‐nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell‐only syndrome infertile patients in the pre...

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Bibliographic Details
Published in:International journal of urology 2019-02, Vol.26 (2), p.292-298
Main Authors: Koc, Gulsah, Ozdemir, Abdullah A, Girgin, Gozde, Akbal, Cem, Kirac, Deniz, Avcilar, Tuba, Guney, Ahmet I
Format: Article
Language:English
Subjects:
array comparative genomic hybridization
Collagen
Collagen (type I)
DNA microarrays
Genes
Genomes
Heterozygosity
Homeobox
Hybridization
Infertility
Loss of heterozygosity
Potassium channels (voltage-gated)
Sertoli cell‐only syndrome
Spermatogenesis
Synaptonemal complex
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Summary:Objectives To detect autosomal genetic defects and to determine candidate genes in Sertoli cell‐only syndrome infertile men. Methods Single‐nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell‐only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage‐gated channel subfamily Q member 1. Conclusions The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell‐only syndrome.
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.13863