Folding of cytosine-based nucleolipid monolayer by guanine recognition at the air-water interface

[Display omitted] Monolayers of a cytosine-based nucleolipid (1,2-dipalmitoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt), CDP-DG) at basic subphase have been prepared at the air-water interface both in absence and presence of guanine. The formation of the complementary base pairing is demon...

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Bibliographic Details
Published in:Journal of colloid and interface science 2019-03, Vol.537, p.694-703
Main Authors: G. Argudo, Pablo, Muñoz, Eulogia, Giner-Casares, Juan José, Martín-Romero, María Teresa, Camacho, Luis
Format: Article
Language:English
Subjects:
Air
Complementary base pairing
Computer simulations
Cytosine - chemistry
Cytosine-based nucleolipid
Guanine - chemistry
Langmuir monolayer
Lipids - chemistry
Molecular Dynamics Simulation
Molecular Structure
Particle Size
Pressure
Surface Properties
Water - chemistry
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Summary:[Display omitted] Monolayers of a cytosine-based nucleolipid (1,2-dipalmitoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt), CDP-DG) at basic subphase have been prepared at the air-water interface both in absence and presence of guanine. The formation of the complementary base pairing is demonstrated by combining surface experimental techniques, i.e., surface pressure (π)–area (A), Brewster angle microscopy (BAM), infrared spectroscopy (PM-IRRAS) and computer simulations. A folding of the cytosine-based nucleolipid molecules forming monolayer at the air-water interface occurs during the guanine recognition as absorbate host and is kept during several compression-expansion processes under set experimental conditions. The specificity between nitrogenous bases has been also registered. Finally, mixed monolayers of CDP-DG and a phospholipid (1,2-dimyristoyl-sn-glycero-3-phosphate (sodium salt), DMPA) has been studied and a molecular segregation of the DMPA molecules has been inferred by the additivity rule.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2018.11.036