Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial

• Published in: Complementary therapies in medicine 2018-12, Vol.41, p.302-305
• Main Authors: Pender, Danielle N., Crawford, Paul F., Clark, Jill M., Crawford, Amanda J., Prats, Alice A., Shah, Sachin A.
• Format: Article
• Language: English
• Subjects: Adult; Blood pressure; Cinnamomum zeylanicum - chemistry; Cinnamon; Diabetes; Dietary supplements; Echocardiography; Electrocardiogram; Electrocardiography; Electrocardiography - drug effects; Fasting; Female; Food; Functional foods & nutraceuticals; Glucose; Health care facilities; Heart rate; Humans; Lifestyles; Male; Medical research; Medicine; Middle Aged; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Prediabetes; QT interval; Safety; Solubility; Subgroups; Water chemistry
• ISSN: 0965-2299; 1873-6963
• DOI: 10.1016/j.ctim.2018.10.009

Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures. [Display omitted] •Cinnamon is lauded as a nutraceutical that can manage prediabetes and diabetes.•Prediabetic subjects consumed daily 1 g of Cinnulin PF for 6 months.•Monitored Cinnulin PF impact on electrocardiographic measures.•No affect from Cinnulin PF on QT interval, QTc interval, PR, QRS, or heart rate. To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes. A subgroup analysis was carried out on data from 103 prediabetic patients participating in the “Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics” trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program. Family Medicine Residency, Mike O’Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency. QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months. Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05). Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.