Off-label Use in Ambulatory Paediatric Clinics in a Central South African Hospital

The aim of this article was to determine off-label (OL) use in paediatric ambulatory clinics in a South African central hospital. OL medicine events were documented in three paediatric clinics (general, highly specialized and dedicated HIV paediatric clinics) at Tygerberg Hospital, South Africa, and...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2019-08, Vol.65 (4), p.380-388
Main Authors: Kruger, Mariana, Makiwane, Memela M, Ramoroka, Sekgele, van Elsland, Sabine L, Lawrence, Katherine, Rosenkranz, Bernd
Format: Article
Language:English
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Summary:The aim of this article was to determine off-label (OL) use in paediatric ambulatory clinics in a South African central hospital. OL medicine events were documented in three paediatric clinics (general, highly specialized and dedicated HIV paediatric clinics) at Tygerberg Hospital, South Africa, and analysed according to South African medicine registration information. There were 2167 medicine events for 658 children. Mean age was 5.6 years (interquartile range 1.8-8.8). There were 123 OL medicine events (6%). Extemporaneous OL use was most common (n = 58, 47%), followed by weight (n = 45, 37%) and lack of paediatric data (n = 38, 31%). Of note was OL use for weight for general paediatrics (n = 32, 78%, p 
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmy065