Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59

• Published in: Alternatives to laboratory animals 2007-03, Vol.35 (1), p.137-154
• Main Authors: Basketter, David, Pease, Camilla, Kasting, Gerald, Kimber, Ian, Casati, Silvia, Cronin, Mark, Diembeck, Walter, Gerberick, Frank, Hadgraft, Jonathan, Hartung, Thomas, Marty, Jean-Paul, Nikolaidis, Efstathios, Patlewicz, Grace, Roberts, David, Roggen, Erwin, Rovida, Costanza, van de Sandt, Johannes
• Format: Article
• Language: English
• Subjects: Allergens - immunology; Allergens - pharmacokinetics; Allergens - toxicity; Animal Testing Alternatives; Animals; Cells, Cultured; Guidelines as Topic; Humans; Risk Assessment; Skin - drug effects; Skin - immunology; Skin - metabolism; Skin Absorption; Skin Tests - methods; Toxicity Tests - methods
• ISSN: 0261-1929; 2632-3559
• DOI: 10.1177/026119290703500124

This is the 59th report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). A workshop on Skin Sensitisation and Epidermal Disposition was held at ECVAM (Ispra, Italy) on 30-31 January 2006, under the chairmanship of David Basketter. The current status of approaches used to measure the disposition of chemicals in skin compartments was reviewed, with particular emphasis on proposing recommendations on how best to use such information to reduce, refine and/or eliminate the need for animal testing, according to the Three Rs principle. The key focus was the relevance of information on epidermal disposition, and how best to integrate such information into non-animal testing strategies for skin sensitisation.