The role of DENND1A and CYP19A1 gene variants in individual susceptibility to obesity in Turkish population—a preliminary study

Single nucleotide polymorphisms (SNPs), the most common genetic variations in human genome, can manage the predisposition of certain complex diseases or situations such as obesity. Genetic polymorphisms also play an important role as they can impact a population’s susceptibility to being overweight...

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Bibliographic Details
Published in:Molecular biology reports 2018-12, Vol.45 (6), p.2193-2199
Main Authors: Kadioglu, Ela, Altun, Beril, İpek, Çağrı, Döğer, Esra, Bideci, Aysun, Attaran, Hadi, Çok, İsmet
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult
Alleles
Animal Anatomy
Animal Biochemistry
Aromatase - genetics
Aromatase - metabolism
Biomedical and Life Sciences
Body Mass Index
Body weight
Cancer
Cardiovascular disease
Case-Control Studies
Child
Coronary artery disease
Death Domain Receptor Signaling Adaptor Proteins - genetics
Death Domain Receptor Signaling Adaptor Proteins - physiology
Diabetes mellitus
Female
Females
Gene frequency
Gene Frequency - genetics
Genetic diversity
Genetic Predisposition to Disease - genetics
Genetic Variation - genetics
Genomes
Genotype
Genotyping
Globulins
Guanine Nucleotide Exchange Factors - genetics
Guanine Nucleotide Exchange Factors - physiology
Heart diseases
Histology
Humans
Life Sciences
Male
Morphology
Obesity
Obesity - genetics
Original Article
Overweight
Polymorphism, Single Nucleotide - genetics
Population
Population genetics
Population studies
Preliminary Data
Single-nucleotide polymorphism
Turkey
Young Adult
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Summary:Single nucleotide polymorphisms (SNPs), the most common genetic variations in human genome, can manage the predisposition of certain complex diseases or situations such as obesity. Genetic polymorphisms also play an important role as they can impact a population’s susceptibility to being overweight or obese and developing related chronic complications such as hypertension, coronary heart disease, diabetes and cancer. The present study comprised of 193 unrelated healthy volunteers (120 females and 73 males) with Turkish origin. Only female adolescents (n = 110) were divided into 2 categories according to their BMI values as overweight (BMI ≥ 25) and normal (18.5 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-018-4380-8