Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-12, Vol.166 (2), p.197-200
Main Authors: Safonova, E. A., Lopatina, K. A., Razina, T. G., Zueva, E. P., Fedorova, E. P., Gur’ev, A. M., Belousov, M. V.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Antitumor activity
Biomedical and Life Sciences
Biomedicine
Carcinoma, Lewis Lung - drug therapy
Carcinoma, Lewis Lung - immunology
Carcinoma, Lewis Lung - pathology
Cell Biology
Cisplatin
Cisplatin - pharmacology
Female
Filgrastim - pharmacology
Granulocytes - drug effects
Granulocytes - immunology
Granulocytes - pathology
Hematologic Agents - pharmacology
Internal Medicine
Laboratory Medicine
Leukocyte Count
Lung carcinoma
Mice
Mice, Inbred C57BL
Neutropenia
Paclitaxel
Paclitaxel - pharmacology
Pathology
Plant Extracts - chemistry
Polysaccharides
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
Treatment Outcome
Tumor Burden - drug effects
Tussilago - chemistry
Tussilago farfara
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Description
Summary:The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4313-5