Prophylactic use of probiotic chocolate modulates intestinal physiological functions in constipated rats

BACKGROUND This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 × 1010 CFU g−1 of probiotics daily for 4 weeks and treated with loperamide (5 mg kg−1) daily at the fourth week of treatment. RESULTS Probiotic c...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2019-04, Vol.99 (6), p.3045-3056
Main Authors: Lee, Chul Sang, Tan, Pei Lei, Eor, Ju Young, Choi, Da Hye, Park, Miri, Seo, Sung Keum, Yoon, Seokmin, Yang, Siyoung, Kim, Sae Hun
Format: Article
Language:English
Subjects:
Abundance
Animals
Aquaporin 8
Bifidobacterium animalis - chemistry
Bifidobacterium animalis - metabolism
Chocolate
Chocolate - analysis
Chocolate - microbiology
Colon
Constipation
Constipation - physiopathology
Constipation - prevention & control
Defecation - drug effects
Feces - microbiology
Female
functional chocolate
gastrointestinal function
Gene expression
Humans
In vivo methods and tests
intestinal barrier function
Intestinal motility
Intestine
Intestines - physiopathology
lactic acid bacteria
Lactobacillus plantarum - chemistry
Lactobacillus plantarum - physiology
Moisture content
Organic chemistry
Polymerase chain reaction
Probiotics
Probiotics - administration & dosage
Probiotics - chemistry
Rats
Rats, Sprague-Dawley
Streptococcus thermophilus - chemistry
Streptococcus thermophilus - physiology
Water content
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Summary:BACKGROUND This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 × 1010 CFU g−1 of probiotics daily for 4 weeks and treated with loperamide (5 mg kg−1) daily at the fourth week of treatment. RESULTS Probiotic chocolate treatment significantly (P 
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.9518