The presence of osteocalcin, osteopontin and reactive oxygen species‐positive cells in pulp tissue after dental bleaching

Aim To analyse the influence of H2O2 on pulp repair through osteocalcin and osteopontin immunolabelling and in cellular defence by using the antireactive oxygen species (ROS) antibody. Methodology The maxillary molars of 50 rats were treated with 35% H2O2 (Ble groups) or placebo gel (control groups)...

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Bibliographic Details
Published in:International endodontic journal 2019-05, Vol.52 (5), p.665-675
Main Authors: Benetti, F., Briso, A. L. F., Carminatti, M., Araújo Lopes, J. M., Barbosa, J. G., Ervolino, E., Gomes‐Filho, J. E., Cintra, L. T. A.
Format: Article
Language:English
Subjects:
Bleaching
Dental pulp
Dentistry
Endodontics
Hydrogen peroxide
Molars
Osteocalcin
Osteopontin
Reactive oxygen species
Teeth
tertiary dentine
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Summary:Aim To analyse the influence of H2O2 on pulp repair through osteocalcin and osteopontin immunolabelling and in cellular defence by using the antireactive oxygen species (ROS) antibody. Methodology The maxillary molars of 50 rats were treated with 35% H2O2 (Ble groups) or placebo gel (control groups). At 0 h and 2, 7, 15 and 30 days (n = 10 hemimaxillae), the rats were killed and pulp tissue was evaluated using inflammation and immunolabelling scores (osteocalcin/osteopontin); ROS‐positive cells were counted. Paired t‐test and Wilcoxon signed‐rank test were used (P  0.05). Osteocalcin was absent in the Ble at 0 h, moderate at 2 days and increased thereafter, differing from the controls at all two periods (P 
ISSN:0143-2885
1365-2591
DOI:10.1111/iej.13049