The N-terminal 14-mer model peptide of human Ctr1 can collect Cu() from albumin. Implications for copper uptake by Ctr1

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 Cu II is bound to the model peptide hCtr1 1-14 via an ATCUN motif and such complexes are strong enough to collect Cu II from albumin, supporting the potential physiological r...

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Bibliographic Details
Published in:Metallomics 2018-12, Vol.1 (12), p.1723-1727
Main Authors: Stefaniak, Ewelina, P onka, Dawid, Drew, Simon C, Bossak-Ahmad, Karolina, Haas, Kathryn L, Pushie, M. Jake, Faller, Peter, Wezynfeld, Nina E, Bal, Wojciech
Format: Article
Language:English
Subjects:
Albumin
Chemical Sciences
Copper
Other
Peptides
Protein transport
Proteins
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Summary:Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 Cu II is bound to the model peptide hCtr1 1-14 via an ATCUN motif and such complexes are strong enough to collect Cu II from albumin, supporting the potential physiological role of Cu II binding to hCtr1. The superior Cu( ii ) affinity of human copper transporter 1 (hCtr1) drives copper acquisition from human serum albumin (HSA).
ISSN:1756-5901
1756-591X
DOI:10.1039/c8mt00274f