Intracavitary slow release paclitaxel polymer in a rodent model of mammary carcinoma

In this study, a pharmacokinetic analysis of the paclitaxel polymer formulation was performed. The formulation was injected subcutaneously in the lower left inguinal area in C3H-HeJ mice. The mice were observed daily for signs of toxicity and local tumor regrowth. Humane sacrifice was performed at d...

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Published in:Journal of bioactive and compatible polymers 2000, Vol.15 (1), p.85-88
Main Authors: BREGAZZI, V. S, DERNELL, W. S, HUBER, D. J, SCHOCHET, R, LAFFERTY, M, OGILVIE, G. K, WITHROW, S. J, POWERS, B. E, MANNING, M
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Blood
Cells
Chemotherapy
Controlled drug delivery
High performance liquid chromatography
Mathematical models
Medical sciences
Oncology
Pharmacokinetics
Pharmacology. Drug treatments
Statistical methods
Toxicity
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container_end_page 88
container_issue 1
container_start_page 85
container_title Journal of bioactive and compatible polymers
container_volume 15
creator BREGAZZI, V. S
DERNELL, W. S
HUBER, D. J
SCHOCHET, R
LAFFERTY, M
OGILVIE, G. K
WITHROW, S. J
POWERS, B. E
MANNING, M
description In this study, a pharmacokinetic analysis of the paclitaxel polymer formulation was performed. The formulation was injected subcutaneously in the lower left inguinal area in C3H-HeJ mice. The mice were observed daily for signs of toxicity and local tumor regrowth. Humane sacrifice was performed at day 15 or sooner if tumor burden or systematic illness indicated the need for earlier sacrifice. Complete necropsies were performed and the local tumor site, lymph nodes, bone marrow, brain, liver, kidneys, spleen, heart, lungs, stomach and intestines removed and placed in formalin for histological assessment of toxicity, metastasis and/or tumor regrowth. Based on the results, it appears that the paclitaxel polymer delivery system decreased local tumor regrowth.
doi_str_mv 10.1106/BLCC-E8VH-EKAN-GWGK
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source SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)
subjects Antineoplastic agents
Biological and medical sciences
Blood
Cells
Chemotherapy
Controlled drug delivery
High performance liquid chromatography
Mathematical models
Medical sciences
Oncology
Pharmacokinetics
Pharmacology. Drug treatments
Statistical methods
Toxicity
title Intracavitary slow release paclitaxel polymer in a rodent model of mammary carcinoma
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