Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta-analysis

The impact of preoperative sarcopenia on long-term survival of esophageal cancer patients after esophagectomy remains unclear. We conducted an updated meta-analysis focusing on current topic comprehensively. We systematically searched relevant studies investigating the impact of preoperative sarcope...

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Bibliographic Details
Published in:Diseases of the esophagus 2019-03, Vol.32 (3)
Main Authors: Deng, Han-Yu, Zha, Panpan, Peng, Lei, Hou, Liang, Huang, Kai-Li, Li, Xiao-Yun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Disease-Free Survival
Esophageal Neoplasms - complications
Esophageal Neoplasms - mortality
Esophageal Neoplasms - surgery
Esophagectomy - mortality
Female
Humans
Male
Middle Aged
Postoperative Complications - etiology
Postoperative Complications - mortality
Preoperative Period
Prognosis
Proportional Hazards Models
Risk Factors
Sarcopenia - complications
Sarcopenia - mortality
Sarcopenia - surgery
Survival Rate
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Summary:The impact of preoperative sarcopenia on long-term survival of esophageal cancer patients after esophagectomy remains unclear. We conducted an updated meta-analysis focusing on current topic comprehensively. We systematically searched relevant studies investigating the impact of preoperative sarcopenia on survival of patients with surgically treated esophageal cancer in PubMed, Embase, and Web of Science up to July 20, 2018. Data of 3-year and 5-year overall survival (OS) rates as well as hazard ratio (HR) of OS and disease-free survival (DFS) were collected for analysis by using the STATA 12.0 package. Finally, a total of 11 cohort studies consisting of 1520 patients (795 sarcopenic patients and 725 nonsarcopenic patients) were included for analysis. Our meta-analysis showed that patients with sarcopenia had a significantly lower 3-year (51.6% vs. 65.4%, P 
ISSN:1120-8694
1442-2050
DOI:10.1093/dote/doy115