Effect of different POS:DOS ratios on hemodynamics at the distal end-to-side anastomosis of a bypass graft

Intimal hyperplasia (IH), especially at the distal end-to-side anastomosis, is a major cause of long term failure of arterial bypass grafts. Hemodynamic factors are believed to be directly related to the development of intimal hyperplasia. The flow ratio between the proximal outlet segment (POS) and...

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Bibliographic Details
Main Authors: Xue-Mei Li, Rittgers, S.E.
Format: Conference Proceeding
Language:English
Subjects:
Arteries
Biomedical engineering
Biomedical measurements
Flow patterns
Flow visualization
Grafts
Hemodynamics
In vitro
Particle tracking
Shear stress
Statistical analysis
Stress
Velocity measurement
Visualization
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Summary:Intimal hyperplasia (IH), especially at the distal end-to-side anastomosis, is a major cause of long term failure of arterial bypass grafts. Hemodynamic factors are believed to be directly related to the development of intimal hyperplasia. The flow ratio between the proximal outlet segment (POS) and the distal outlet segment (DOS) may be one of the factors which influence the hemodynamic environment in the anastomosis. This is of interest since two recent studies have shown that the site of greatest IH formation varies from the artery floor to the graft hood under occluded vs. partial POS outflow, respectively. In this study, a pulsatile flow in vitro model of the distal end-to-side anastomosis of an arterial bypass graft was used to examine the effects that different POS:DOS flow ratios have on the flow patterns and the distributions of hemodynamic factors in the anastomosis.
ISSN:1094-687X
0589-1019
1558-4615
DOI:10.1109/IEMBS.1999.802239