Chemiluminescent method for determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline

A chemiluminescent method is described for the determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline. The method is based on the photon counting technique and the spline functions approximation. The simple formula S = b + Ax2 is proposed for the observed depe...

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Bibliographic Details
Published in:BIOPOLYM 2000, Vol.57 (6), p.365-372
Main Author: Marczynski, Slawomir
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - pharmacokinetics
Approximation theory
Biopolymers
Chemiluminescence
Correlation methods
Drug products
Functions
Half-Life
Humans
Luminescent Measurements
Metals
Methods
Oxidants
photon counting
Photons
Temperature
tetracyclines
Tetracyclines - analysis
Tetracyclines - pharmacokinetics
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Summary:A chemiluminescent method is described for the determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline. The method is based on the photon counting technique and the spline functions approximation. The simple formula S = b + Ax2 is proposed for the observed dependency of the integrated number of countings S on the concentration x of a given antibiotic. The correlation between S and the half‐life of a drug in the human body is proved. © 2000 John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 57: 365–372, 2000
ISSN:0006-3525
1097-0282
DOI:10.1002/1097-0282(2000)57:6<365::AID-BIP60>3.0.CO;2-R