Formulation of an injectable phosphocalcium cement

In orthopedic surgery, the loss or the reinforcement of osseous substance often requires filling of the defective part. In order to make the surgical operations easier we sought to make an injectable form. This study examined the effect of silicone and polyglycol on the injectability, setting time a...

Full description

Saved in:
Bibliographic Details
Published in:Key engineering materials 2001-01, Vol.192-195, p.789-792
Main Authors: Goncalves, S, Brouchet, A, Freche, M, Rodriguez, F, Delisle, B, Lacout, J L
Format: Article
Language:English
Subjects:
Additives
Calcium compounds
Composition effects
Glycols
Implants (surgical)
Setting
Silicones
Transplantation (surgical)
Viscosity
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In orthopedic surgery, the loss or the reinforcement of osseous substance often requires filling of the defective part. In order to make the surgical operations easier we sought to make an injectable form. This study examined the effect of silicone and polyglycol on the injectability, setting time and mechanical properties of the cement. The basic solid phase was composed of a mixture of tetracalcium phosphate (Ca sub(4)(PO sub(4)) sub(2)O), alpha -tricalcium phosphate (Ca sub(3)(PO sub(4)) sub(2)) and sodium glycerophosphate. The basic liquid phase was made up of lime, orthophosphoric acid and water. Silicone was previously dissolved in cyclohexane and introduced in the solid phase. Polyglycol is a water-soluble compound so it is introduced in the liquid phase. For the mechanical properties, the strong increase in the percentage of additives decreased the compressive strength. Silicone and polyglycol made it possible to improve viscosity without modifying the basic setting time. The rate of evolution was different with the two different additives. From the data it was possible to optimize the formulation of cements to give predicted properties. Testing the in vivo implantation of the cement has already started. Preliminary results show the perfect osteointegration of the new cements without reactions to the foreign body in spite of the presence of silicone.
ISSN:1013-9826