Polycaprolactone microparticles and their biodegradation

Polycaprolactone (PCL) microparticles were prepared by an emulsification-solvent evaporation technique using various stabilizers such as gelatin, hydrophobically modified polyacrylamide derivative (PAM) and poly(vinyl alcohol) (PVA). It was shown that the particle size distribution of PCL microparti...

Full description

Saved in:
Bibliographic Details
Published in:Polymer degradation and stability 2000-03, Vol.67 (3), p.455-459
Main Authors: Chen, D.R, Bei, J.Z, Wang, S.G
Format: Article
Language:English
Subjects:
Applied sciences
Biodegradation
Chemical reactions and properties
Crystal structure
Crystallinity
Degradation
Emulsification
Evaporation
Exact sciences and technology
Lipase
Microparticles
Organic polymers
Particle size analysis
Physicochemistry of polymers
Plastic films
Polycaprolactone
Polyvinyl alcohols
Solvents
Stabilizers (agents)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polycaprolactone (PCL) microparticles were prepared by an emulsification-solvent evaporation technique using various stabilizers such as gelatin, hydrophobically modified polyacrylamide derivative (PAM) and poly(vinyl alcohol) (PVA). It was shown that the particle size distribution of PCL microparticles was 13.4±4.7 (μm) in diameter with gelatin as stabilizer. The degradation behavior of the PCL microparticles was determined and compared with that of PCL film at pH 7.4 at 37±1°C with and without lipase. The shape of PCL had no obvious effect on its degradation rate. It suggested that homogeneous degradation dominated the process. The degradation rate of PCL microparticles was enhanced in the presence of lipase enzyme. The degree of crystallinity of PCL microparticles increased with degradation, proving preferential degradation in amorphous domains of the PCL microparticles.
ISSN:0141-3910
1873-2321
DOI:10.1016/S0141-3910(99)00145-7