Development of an automated single cell irradiation system combined with a high-energy heavy ion microbeam system

An automated single cell recognition and irradiation system has been developed at a high-energy heavy ion microbeam. The system has been installed on a vertical beam line of the JAERI Takasaki AVF-cyclotron accelerator to irradiate individual biological cells in an air environment with energies of m...

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Bibliographic Details
Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 2001-07, Vol.181 (1), p.27-31
Main Authors: Kamiya, Tomihiro, Yokota, Watalu, Kobayashi, Yasuhiko, Cholewa, Marian, Krochmal, Michael S, Laken, Garey, Larsen, Ian D, Fiddes, Leigh, Parkhill, Graham, Dowsey, Kevin
Format: Article
Language:English
Subjects:
Automated
Cell
Cells
Charge coupled devices
Computer networks
Computer software
Cyclotron radiation
Irradiation
Microbeam
Optical microscopy
Optical systems
Particle accelerators
Radiation effects
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Summary:An automated single cell recognition and irradiation system has been developed at a high-energy heavy ion microbeam. The system has been installed on a vertical beam line of the JAERI Takasaki AVF-cyclotron accelerator to irradiate individual biological cells in an air environment with energies of more than 10 MeV/u by single ions. The system consists of high-precision stages, optical microscopes with CCD camera, a computer network and software packages to obtain positional data from a cluster of individual samples randomly placed on a holder before irradiation and to irradiate them with individual ions according to the obtained data. This paper will describe the new systems, and show results from irradiation experiments for CR-39.
ISSN:0168-583X
1872-9584
DOI:10.1016/S0168-583X(01)00550-X