Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes

Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino...

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Bibliographic Details
Published in:Transition metal chemistry (Weinheim) 2000-01, Vol.25 (4), p.369-373
Main Authors: Offiong, Offiong E, N, Emmanuel, Ayi, Ayi A, Martelli, Sante
Format: Article
Language:English
Subjects:
Amino acids
Electric conductivity measurement
Electron spectroscopy
Infrared spectroscopy
Nuclear magnetic resonance spectroscopy
Spectrum analysis
Synthesis (chemical)
Toxicity
Tumors
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Summary:Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd^sup II^ and Pt^sup II^ complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.[PUBLICATION ABSTRACT]
ISSN:0340-4285
1572-901X
DOI:10.1023/A:1007055304150