Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes

Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino...

Full description

Saved in:
Bibliographic Details
Published in:Transition metal chemistry (Weinheim) 2000-01, Vol.25 (4), p.369-373
Main Authors: Offiong, Offiong E, N, Emmanuel, Ayi, Ayi A, Martelli, Sante
Format: Article
Language:English
Subjects:
Amino acids
Electric conductivity measurement
Electron spectroscopy
Infrared spectroscopy
Nuclear magnetic resonance spectroscopy
Spectrum analysis
Synthesis (chemical)
Toxicity
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c257t-f6820e9c5fc52b352bf2ded4d41e7f0c8ae4aaf4676fa5741ece432b8589f8d93
cites
container_end_page 373
container_issue 4
container_start_page 369
container_title Transition metal chemistry (Weinheim)
container_volume 25
creator Offiong, Offiong E
N, Emmanuel
Ayi, Ayi A
Martelli, Sante
description Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd^sup II^ and Pt^sup II^ complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.[PUBLICATION ABSTRACT]
doi_str_mv 10.1023/A:1007055304150
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_21449203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>479803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c257t-f6820e9c5fc52b352bf2ded4d41e7f0c8ae4aaf4676fa5741ece432b8589f8d93</originalsourceid><addsrcrecordid>eNpdjktLAzEUhYMoWB9rt8GFKDh68-pk3JXio1BwUQV3JU1uaMrMZGwy0P57Bx8bF4cDh4_DR8gFgzsGXNxPHhhACUoJkEzBARkxVfKiAvZxSEYgJBSSa3VMTlLaAIDipRyRuNi3eY0ppFuaOrR5a2pqWkftPsccd8GGvKcp9y5gotHTztS1caFvrmezm2-yq00O7d_QhDZSY4OjC7sO3tOVSUhtbLoad5jOyJE3dcLz3z4l70-Pb9OXYv76PJtO5oXlqsyFH2sOWFnlreIrMcRzh046ybD0YLVBaYyX43LsjSqH1aIUfKWVrrx2lTglVz-_3TZ-9pjysgnJ4uDeYuzTkjMpKw5iAC__gZvYb9vBbam1qPSYSyG-ABlhacE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>883986243</pqid></control><display><type>article</type><title>Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes</title><source>Springer Nature</source><creator>Offiong, Offiong E ; N, Emmanuel ; Ayi, Ayi A ; Martelli, Sante</creator><creatorcontrib>Offiong, Offiong E ; N, Emmanuel ; Ayi, Ayi A ; Martelli, Sante</creatorcontrib><description>Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd^sup II^ and Pt^sup II^ complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0340-4285</identifier><identifier>EISSN: 1572-901X</identifier><identifier>DOI: 10.1023/A:1007055304150</identifier><language>eng</language><publisher>Dordrecht: Springer Nature B.V</publisher><subject>Amino acids ; Electric conductivity measurement ; Electron spectroscopy ; Infrared spectroscopy ; Nuclear magnetic resonance spectroscopy ; Spectrum analysis ; Synthesis (chemical) ; Toxicity ; Tumors</subject><ispartof>Transition metal chemistry (Weinheim), 2000-01, Vol.25 (4), p.369-373</ispartof><rights>Kluwer Academic Publishers 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c257t-f6820e9c5fc52b352bf2ded4d41e7f0c8ae4aaf4676fa5741ece432b8589f8d93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Offiong, Offiong E</creatorcontrib><creatorcontrib>N, Emmanuel</creatorcontrib><creatorcontrib>Ayi, Ayi A</creatorcontrib><creatorcontrib>Martelli, Sante</creatorcontrib><title>Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes</title><title>Transition metal chemistry (Weinheim)</title><description>Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd^sup II^ and Pt^sup II^ complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.[PUBLICATION ABSTRACT]</description><subject>Amino acids</subject><subject>Electric conductivity measurement</subject><subject>Electron spectroscopy</subject><subject>Infrared spectroscopy</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Spectrum analysis</subject><subject>Synthesis (chemical)</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>0340-4285</issn><issn>1572-901X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpdjktLAzEUhYMoWB9rt8GFKDh68-pk3JXio1BwUQV3JU1uaMrMZGwy0P57Bx8bF4cDh4_DR8gFgzsGXNxPHhhACUoJkEzBARkxVfKiAvZxSEYgJBSSa3VMTlLaAIDipRyRuNi3eY0ppFuaOrR5a2pqWkftPsccd8GGvKcp9y5gotHTztS1caFvrmezm2-yq00O7d_QhDZSY4OjC7sO3tOVSUhtbLoad5jOyJE3dcLz3z4l70-Pb9OXYv76PJtO5oXlqsyFH2sOWFnlreIrMcRzh046ybD0YLVBaYyX43LsjSqH1aIUfKWVrrx2lTglVz-_3TZ-9pjysgnJ4uDeYuzTkjMpKw5iAC__gZvYb9vBbam1qPSYSyG-ABlhacE</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Offiong, Offiong E</creator><creator>N, Emmanuel</creator><creator>Ayi, Ayi A</creator><creator>Martelli, Sante</creator><general>Springer Nature B.V</general><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20000101</creationdate><title>Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes</title><author>Offiong, Offiong E ; N, Emmanuel ; Ayi, Ayi A ; Martelli, Sante</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-f6820e9c5fc52b352bf2ded4d41e7f0c8ae4aaf4676fa5741ece432b8589f8d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amino acids</topic><topic>Electric conductivity measurement</topic><topic>Electron spectroscopy</topic><topic>Infrared spectroscopy</topic><topic>Nuclear magnetic resonance spectroscopy</topic><topic>Spectrum analysis</topic><topic>Synthesis (chemical)</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Offiong, Offiong E</creatorcontrib><creatorcontrib>N, Emmanuel</creatorcontrib><creatorcontrib>Ayi, Ayi A</creatorcontrib><creatorcontrib>Martelli, Sante</creatorcontrib><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Transition metal chemistry (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Offiong, Offiong E</au><au>N, Emmanuel</au><au>Ayi, Ayi A</au><au>Martelli, Sante</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes</atitle><jtitle>Transition metal chemistry (Weinheim)</jtitle><date>2000-01-01</date><risdate>2000</risdate><volume>25</volume><issue>4</issue><spage>369</spage><epage>373</epage><pages>369-373</pages><issn>0340-4285</issn><eissn>1572-901X</eissn><abstract>Novel Pd^sup II^ and Pt^sup II^ complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and ^sup 1^H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd^sup II^ and Pt^sup II^ complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.[PUBLICATION ABSTRACT]</abstract><cop>Dordrecht</cop><pub>Springer Nature B.V</pub><doi>10.1023/A:1007055304150</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0340-4285
ispartof Transition metal chemistry (Weinheim), 2000-01, Vol.25 (4), p.369-373
issn 0340-4285
1572-901X
language eng
recordid cdi_proquest_miscellaneous_21449203
source Springer Nature
subjects Amino acids
Electric conductivity measurement
Electron spectroscopy
Infrared spectroscopy
Nuclear magnetic resonance spectroscopy
Spectrum analysis
Synthesis (chemical)
Toxicity
Tumors
title Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T02%3A21%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20spectral%20and%20cytotoxicity%20studies%20of%20palladium(II)%20and%20platinum(II)%20amino%20acid%20Schiff%20base%20complexes&rft.jtitle=Transition%20metal%20chemistry%20(Weinheim)&rft.au=Offiong,%20Offiong%20E&rft.date=2000-01-01&rft.volume=25&rft.issue=4&rft.spage=369&rft.epage=373&rft.pages=369-373&rft.issn=0340-4285&rft.eissn=1572-901X&rft_id=info:doi/10.1023/A:1007055304150&rft_dat=%3Cproquest%3E479803%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c257t-f6820e9c5fc52b352bf2ded4d41e7f0c8ae4aaf4676fa5741ece432b8589f8d93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=883986243&rft_id=info:pmid/&rfr_iscdi=true