Study on highly sensitive potentiometric IgG immunosensor

A novel potentiometric immunosensor for detection of immunogloblin G (IgG) has been developed by means of covalent immobilization of anti-immunogloblin G on a silver (Ag) electrode. The detection is based on the change in the electric potential before and after the antigen–antibody reaction. Tests r...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2000-07, Vol.66 (1), p.190-192
Main Authors: Feng, Chun-liang, Xu, Yi-hong, Song, Li-min
Format: Article
Language:English
Subjects:
Antigen-antibody reactions
Electrochemical electrodes
Potentiometric sensors
Silver
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Summary:A novel potentiometric immunosensor for detection of immunogloblin G (IgG) has been developed by means of covalent immobilization of anti-immunogloblin G on a silver (Ag) electrode. The detection is based on the change in the electric potential before and after the antigen–antibody reaction. Tests relating to the detection of IgG demonstrate that the immunosensor exhibits a high level of sensitivity, stability and reproducibility, the linear response range was 0.2–1.2 ng/ml for IgG solution and the lifetime was more than 28 days.
ISSN:0925-4005
1873-3077
DOI:10.1016/S0925-4005(00)00382-8