Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO 2, and pO 2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When int...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2000-09, Vol.69 (1), p.183-188
Main Authors: Cooney, Christopher G, Towe, Bruce C, Eyster, Curt R
Format: Article
Language:English
Subjects:
Absorbance
Blood gas
Blood gas analysis
Dialysis
Fluorescence
Micro-flow and optical monitoring
Microdialysis
Optical systems
Oxygen sensors
Patient monitoring
pH sensors
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Summary:Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO 2, and pO 2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO 2, and ±1.5 mm Hg pO 2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO 2, and pO 2, respectively.
ISSN:0925-4005
1873-3077
DOI:10.1016/S0925-4005(00)00544-X