Extracellular matrix scaffold for myocardial repair

UBS and SIS were used as a scaffold for the repair of the right ventricular free wall and right ventricular outflow tract in a porcine animal model. Surgically-created, full-thickness defects in the right ventricle, were repaired with a single layer sheet of UBS or SIS. Animals were sacrificed at pe...

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Bibliographic Details
Published in:Annals of biomedical engineering 2000-01, Vol.28 (SUPPL. 1), p.S-119
Main Authors: Badylak, Stephen, Tullius, Robert, Matheny, Robert
Format: Article
Language:English
Subjects:
Biological organs
Cardiology
Cardiovascular system
Cells
Muscle
Online Access:Get full text
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Summary:UBS and SIS were used as a scaffold for the repair of the right ventricular free wall and right ventricular outflow tract in a porcine animal model. Surgically-created, full-thickness defects in the right ventricle, were repaired with a single layer sheet of UBS or SIS. Animals were sacrificed at periods of time ranging from 6 weeks to 5 months post surgery. In vitro contractility tests showed that the remodeled tissue could generate contractile forces up to 70% of that produced by native myocardium.
ISSN:0090-6964