Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB sub(2) agonists for the treatment of inflammatory pain

A series of 3-amino-6-aryl-pyridazines have been identified as CB sub(2) agonists with high efficacy and selectivity against the CB sub(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35, a comp...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2010-01, Vol.20 (2), p.465-468
Main Authors: Gleave, Robert J, Beswick, Paul J, Brown, Andrew J, Giblin, Gerard MP, Goldsmith, Paul, Haslam, Carl P, Mitchell, William L, Nicholson, Neville H, Page, Lee W, Patel, Sadhana, Roomans, Susan, Slingsby, Brian P, Swarbrick, Martin E
Format: Article
Language:English
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Summary:A series of 3-amino-6-aryl-pyridazines have been identified as CB sub(2) agonists with high efficacy and selectivity against the CB sub(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35, a compound with high potency in an in vivo model of inflammatory pain.
ISSN:0960-894X
DOI:10.1016/j.bmcl.2009.11.117