Robust control of drug infusion with time delays using direct adaptive control: experimental results

The control of hemodynamic variables, particularly mean arterial pressure and cardiac output, is a challenging problem. Due to the complex, nonlinear behavior of the system, a good controller is difficult to design. In addition, there are significant changes in dynamics from one patient to another,...

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Bibliographic Details
Main Authors: Palerm, C.C., Bequette, B.W., Ozcelik, S.
Format: Conference Proceeding
Language:English
Subjects:
Algorithms
Blood pressure
Closed loop control systems
Control systems
Delay effects
Drug infusion
Drugs
Feedback control
Hemodynamics
Linear control systems
Mathematical models
Nonlinear control systems
Nonlinear dynamical systems
Pressure control
Programmable control
Robust control
Robustness (control systems)
Transfer functions
Uncertain systems
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Summary:The control of hemodynamic variables, particularly mean arterial pressure and cardiac output, is a challenging problem. Due to the complex, nonlinear behavior of the system, a good controller is difficult to design. In addition, there are significant changes in dynamics from one patient to another, and even variations in the patient's response to the drugs as his condition evolves. A robust direct model reference adaptive controller is developed for such plants with uncertainty in both the time delay elements and in the transfer function coefficients. Further modifications are introduced as well to handle command limiting. The controller developed is then validated with dog experiments. The experiments were conducted on three mongrel dogs, using different drug combinations and different anesthetics.
ISSN:0743-1619
2378-5861
DOI:10.1109/ACC.2000.879110