Functionalized DNA: A New Replicable Biopolymer

New DNA: By enzymatic polymerization of base‐modified nucleoside triphosphates, a functionalized DNA (fDNA; see picture) was generated in which every base bears an additional amino acid like residue, thus mimicking the functional group repertoire of peptides on a nucleic acid backbone. These modifie...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2001-11, Vol.40 (21), p.3990-3993
Main Authors: Thum, Oliver, Jäger, Stefan, Famulok, Michael
Format: Article
Language:English
Subjects:
Amino acids
Biopolymers
combinatorial chemistry
in vitro selection
nucleotides
oligonucleotides
Polymerization
Online Access:Get full text
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Summary:New DNA: By enzymatic polymerization of base‐modified nucleoside triphosphates, a functionalized DNA (fDNA; see picture) was generated in which every base bears an additional amino acid like residue, thus mimicking the functional group repertoire of peptides on a nucleic acid backbone. These modified oligonucleotides can in turn serve as templates for polymerase chain reaction amplification, thus utilizing fDNA as a novel class of biopolymers for in vitro selection techniques.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011105)40:21<3990::AID-ANIE3990>3.0.CO;2-O