Accurate Assessment of Risk of Major Malformations in Infants With First-Trimester Exposure to Quetiapine

Spinelli expresses insights on the accurate assessment of the risk of major malformations in infants with first-trimester exposure to quetiapine. Childbirth is a powerful trigger for psychiatric illnesses that carry considerable morbidity and mortality. Adverse obstetric and neonatal outcomes among...

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Bibliographic Details
Published in:The American journal of psychiatry 2018-12, Vol.175 (12), p.1161-1162
Main Author: Spinelli, Margaret G
Format: Article
Language:English
Subjects:
Antipsychotic Agents
Behavior disorders
Clinical outcomes
Female
Humans
Infant mortality
Pregnancy
Pregnancy complications
Pregnancy Trimester, First
Quetiapine Fumarate
Risk factors
Side effects
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Summary:Spinelli expresses insights on the accurate assessment of the risk of major malformations in infants with first-trimester exposure to quetiapine. Childbirth is a powerful trigger for psychiatric illnesses that carry considerable morbidity and mortality. Adverse obstetric and neonatal outcomes among women with psychosis at the time of delivery include heightened risk for cesarean delivery, antepartum and postpartum hemorrhage, placental abruption, poor fetal growth and prematurity, stillbirth, fetal abnormalities, and fetal distress. Here, the author explores the study by Cohen and colleagues on the safety of quetiapine to determine the relative risk of major malformations in a cohort exposed during the first trimester compared with a nonexposed control group of pregnant women.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2018.18070877