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Optical coherence tomography analysis of the inner retinal layers in children

The aim of this study was to determine a correlation between the optic nerve head (ONH) area, the peripapillary retinal nerve fibre layer (pRNFL), and the ganglion cell inner plexiform layer (GCIPL) thicknesses, measured by optical coherence tomography (OCT) in children. Cross-sectional study of 358...

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Bibliographic Details
Published in:Canadian journal of ophthalmology 2018-12, Vol.53 (6), p.614-620
Main Authors: Gama, Rita, Santos, Joana Chambel, Costa, Rute Sousa, da Costa, Daniela Cândido, Eirô, Nuno
Format: Article
Language:English
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Summary:The aim of this study was to determine a correlation between the optic nerve head (ONH) area, the peripapillary retinal nerve fibre layer (pRNFL), and the ganglion cell inner plexiform layer (GCIPL) thicknesses, measured by optical coherence tomography (OCT) in children. Cross-sectional study of 358 eyes in 358 children, 187 belonging to males (52.2%), having a mean age of 6.41 ± 1.66 years and spherical equivalent 0.22 ± 0.50 D. All subjects were imaged with Cirrus HD-OCT. ONH parameters, pRNFL, and macula thicknesses maps for each subject were obtained. Average pRNFL thickness was 100.19 ± 10.10 μm and average GCIPL thickness was 85.29 ± 5.54 μm. Thirty-eight eyes (10.6%) had megalopapilla. A positive correlation was found between pRNFL thickness and the ONH area, GCIPL thickness and the ONH area, and pRNFL and GCIPL thicknesses. In children, a positive correlation was found between pRNFL and GCIPL thicknesses and the ONH area. As the ONH area increases, the pRNFL and GCIPL thicknesses measured by OCT increase, supporting the histological observations that large discs have a higher number of ganglion cells. Consequently, the fixed diameter of the OCT scan does not influence these measurements. We suggest that a future normative database of OCT measurements adapted to children adjust the pRNFL and GCIPL thicknesses with the ONH area. Cette étude avait pour objectif d’établir une corrélation entre l’aire de la tête du nerf optique (TNO), l’épaisseur des couches de fibres nerveuses rétiniennes péripapillaires (pRNFL, pour peripapillary retinal nerve fiber layer) et celle des cellules ganglionnaires de la couche plexiforme interne (GCIPL, pour ganglion cell inner plexiform layer), mesurées par tomographie en cohérence optique (OCT, pour optical coherence tomography) chez des enfants. Étude transversale intéressant 358 yeux de 358 enfants, dont 187 étaient des garçons (52,2 %) et dont l’âge moyen était de 6,41 ± 1,66 an. L’équivalent sphérique se chiffrait à 0,22 ± 0,50 D. Toutes les images ont été obtenues au moyen du HD-OCT de Cirrus. On a mesuré l’aire de la TNO ainsi que l’épaisseur des pRNFL et de la macula de chaque sujet. L’épaisseur moyenne des pRNFL s’élevait à 100,19 ± 10,10 μm, tandis que l’épaisseur moyenne des GCIPL était de 85,29 ± 5,54 μm. Trente-huit yeux (10,6 %) présentaient une mégalopapille. On a observé une corrélation positive entre l’épaisseur des pRNFL et l’aire de la TNO, entre l’épaisseur des GCIPL et l’aire de la TNO de même qu’entr
ISSN:0008-4182
1715-3360
DOI:10.1016/j.jcjo.2018.02.025