Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

Coupling of thiol and urea-type -NHC([double bond, length as m-dash]X)NH2 (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (6), p.759-762
Main Authors: Okada, Shunsuke, Matsusaki, Motonori, Arai, Kenta, Hidaka, Yuji, Inaba, Kenji, Okumura, Masaki, Muraoka, Takahiro
Format: Article
Language:English
Subjects:
Coupling
Folding
Protein folding
Proteins
Ureas
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Summary:Coupling of thiol and urea-type -NHC([double bond, length as m-dash]X)NH2 (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields of native proteins.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc08657e