Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection

•IgA and eosinophil are less repeatable in goats than sheep in nematode infection.•IgA and eosinophil have positive associations with faecal egg counts in goats.•Structural model suggests that IgA receptor on eosinophils is dysfunctional in goats.•Goats appear to lack effective IgA and eosinophil re...

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Bibliographic Details
Published in:Veterinary parasitology 2018-12, Vol.264, p.18-25
Main Authors: Basripuzi, N. Hayyan, Salisi, M. Shahrom, Isa, N. Mahiza Md, Busin, Valentina, Cairns, Callum, Jenvey, Caitlin, Stear, Michael J.
Format: Article
Language:English
Subjects:
Animals
Eosinophil
Eosinophils - immunology
Goat Diseases - immunology
Goat Diseases - parasitology
Goats
IgA
Immune response
Immunoglobulin A - immunology
Nematoda - immunology
Nematode
Nematode Infections - immunology
Nematode Infections - veterinary
Parasite Egg Count - veterinary
Sheep
Teladorsagia circumcincta
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Summary:•IgA and eosinophil are less repeatable in goats than sheep in nematode infection.•IgA and eosinophil have positive associations with faecal egg counts in goats.•Structural model suggests that IgA receptor on eosinophils is dysfunctional in goats.•Goats appear to lack effective IgA and eosinophil responses against nematodes. Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2018.10.014